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In RAW264.7 cells, mRNAs containing m 5 C or a combination of m 5 C + inhibited the secretion of IFN-, IL-6, TNF-, and IL-1 more efficiently than both unmodified mRNA and 2sU-modified mRNA, with the effect being dose-dependent [256]

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The facet joints in the spine may increase in size due to osteoporosis or Pagets disease, forming bone spurs, narrowing the passageways, and ultimately compressing the nerve roots

It may not be surprising that it may benefit bone repair as well

Preclinical potency benchmark Tomas et al