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According to KEGG pathway analysis, the cAMP signaling pathway (hsa04024), MAPK signaling pathway (hsa04010), Neuroactive ligand-receptor interaction (hsa04080), T-cell receptor signaling pathway (hsa04660), Relaxin signaling pathway (hsa04926), Calcium signaling pathway (hsa04020), Ras signaling pathway (hsa04014), PI3K-Akt signaling pathway (hsa04151), Neurotrophin signaling pathway (hsa04722) are highly enriched (Figure 11C)

Dai et al

By suppressing pro-inflammatory cytokine production at the transcriptional level, KPV addresses a root cause of inflammatory nerve damage

Inability to self-administer the intranasal spray, except with assistance from a spouse or home care nurse