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FDA intends for this guidance to assist sponsors in the clinical development of nicotine replacement therapy (NRT) drug products intended to help cigarette smokers stop smoking

1 Smoking also increases the production of mucus

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Regarding this association, possible biological mechanisms elucidating the impact of smoking on anxiety include an array of processes, including the dopaminergic system, gamma-aminobutyric acid, hypothalamic-pituitary-adrenal axis, serotonin, and monoamine oxidase 26-28

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