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Similarly, hypoxia-inducible factor 1-alpha (HIF-1) upregulates the miR-23a/24 cluster, driving a metabolic shift toward glycolysis under hypoxic conditions and thereby accelerating cancer progression [112]

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Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia

Participants who experienced significant nausea, vomiting, or other gastrointestinal symptoms during escalation could have their dose increase paused or delayed until symptoms resolved

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