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One of the key mechanisms involves the upregulation of tyrosine hydroxylase (TH), a critical enzyme in dopamine biosynthesis

Interestingly, TFR1 had been previously identified as the major cell surface receptor for IgA1 binding in renal mesangial cells and its overexpression has been correlated with the proliferation of mesangial cells in IgAN patients [269,270,271]

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For example, USP19 promotes adipogenesis and exacerbates high-fat-diet-induced obesity and glucose intolerance in mice

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