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These include long-term safety, optimal dosing, and the durability of its skin-lightening effects

ED is an early warning sign of cardiovascular disease [5], and it is also strongly associated with metabolic diseases [6]

Just as the normal (conventional) ranges for TSH may not be optimal, the normal lab values for B12 and ferritin may not be in what functional practitioners (including myself) would consider an ideal range either

These effects were recapitulated in CDO1-overexpressing hepatocytes

If you find out that you have one or more of the gene mutations, you can supplement with methyl-folate and methyl B12, the active forms of these B vitamins