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Its expression correlates positively with beneficial bacteria such as Bacteroides and members of Actinobacteria and is tightly regulated by cytokines (e.g., TNF, IFN, IL4, TGF) and chemokines (e.g., CXCL12/CXCR4) [89]

A bifunctional fusion protein targeting PD-L1 and TGF-, in patients with heavily pretreated CRC: Preliminary results from a phase I trial

Most people require 8 to 12 weeks of daily use before visible skin changes appear