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Acknowledgments We would like to thank Nicola Ryan, who edited a preliminary draft of this manuscript on behalf of Springer Healthcare Communications

On the other hand, the thioether bridge is believed to be formed independently by the active copper center via an autocatalytic process and is thus likely to be present 55

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Studies using chondrocyte cell models have investigated whether the GH C-terminal fragment influences cartilage matrix synthesis, chondrocyte proliferation, and growth factor expression in bone and cartilage biology research contexts

The copper-peptide complex stimulates fibroblast proliferation, enhances collagen and elastin synthesis, improves angiogenesis, and supports antioxidant defense mechanisms