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Additionally, the integrated HIV-1 provirus is approximately 9700 bp in length, and HIV-1 Rev binds directly to the Rev response element, leading to the accumulation of unspliced, partially spliced, and fully spliced RNA species, as well as rare cryptic splice donors (5 splice sites) and acceptors (3 splice sites) [38]

Some individuals may respond well to one drug but not to another due to difference in the underlying cause of their disease condition (Unnikrishnan et al., 2021)

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Efficiency of CREM knockdown by siRNA (n = 3) or CREM over-expression (n = 4) in HL-60 cells validated by qPCR ( c ) and western blot ( d )