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Following its release, most B 12 is absorbed by the body in the small bowel (ileum) after binding to a protein known as intrinsic factor

Understanding this decline helps explain why recovery and tissue integrity change over time

Plays a critical role in the proper function of white blood cells, including T cell lymphocytes and the multiplication of lymphocytes (the cells that mediate specific immunity)

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Here, we classify astroglial pathophysiology into (i) reactive astrogliosis, (ii) astroglial atrophy with loss of function, (iii) astroglial degeneration and death, and (iv) astrocytopathies characterised by aberrant forms that drive disease