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475,480,481 The encouraging results obtained with semaglutide in patients with heart failure and a preserved ejection fraction may provide a new option for this patient population, in which additional therapy, as well as another upstream therapy for patients with a higher BMI who have indications for this condition, is urgently needed

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The observed accumulation of GSH in Sp treated cells was probably due to reduced activity of -glutamyl transpeptidase (GGT), an enzyme responsible for glutathione catabolism 36