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Randomized controlled trials are needed to adequately evaluate lymph node involvement and compare various therapeutic strategies, so that standardization may be attempted and initial treatment protocols elaborated to determine the best combination of greatest efficacy with least morbidity

So, a pack a day smoker would get the equivalent amount of nicotine in an e-cigarette refill compared to a pack of cigarettes for between 1.50 to 2.00 a day

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