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Cost-minimization analysis in a blind randomized trial on small-incision versus laparoscopic cholecystectomy from a societal perspective: sick leave outweighs efforts in hospital savings

established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present

In the acute toxicity test of fenugreek ethanol seed extract at a dose of 3,000 mg/kg, no severe signs of toxicity or mortality were observed, though there was a mild increase in respiration and excitation, indicating that the extract was relatively less toxic at this dose