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Beta-3 adrenergic receptors, the primary target of AOD-9604, are highly expressed in white and brown adipose tissue but have minimal presence in appetite-regulating brain regions

Used Annals of the New York Academy of Sciences 70% of the Immune System Resides in the Gut Approximately 70% of the immune system lives in the gut (gut-associated lymphoid tissue)

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There's limited evidence that doses above 600mcg provide additional benefit