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This study established a mechanistic link between integrin signaling and the production of 27-HC, an immunosuppressive oxysterol known to induce CD8 + T cell exhaustion within the TME

Hyperlipidemia treatment were given to group 2 (HCD) and group 3 (HCD+VOO) as described above in experimental design

The current study (protocol# 2019006) was approved by the Institutional Review Board for human study of Wenzhou Medical University and conducted according to the principles expressed in the Helsinki Declaration

Uncovering the efficacy and mechanism of zhenwu decoction for hypothyroidism based on non-targeted metabolomics