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Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells

The NPs (10 L, 2.5 mg kg 1 ) and PBS (10 L) were delivered by intra-articular injection into the right knee of the OA mice at 4 weeks and 6 weeks post-surgery, respectively

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Additional research has examined the peptide's influence on fibroblast migration and collagen-associated signaling, which are important elements of connective tissue remodeling and structural tissue organization