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Estrogen is synthesized in the following tissues:[ref] ovaries (major source in women, E2) testes (males) fat cells (E1, especially post-menopause) brain liver pancreas intestines adrenals The precursor for estrogen is cholesterol, which is first converted (using CYP11A1) into progesterone, which is then converted (using CYP17A1) into androstenedione

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W., Fasano, A., Miller, G

Oxidative stress is an imbalance where there are too many free radicals and not enough antioxidants to keep them in check

When the DNA is mutated by a free radical stealing an electron from the DNA, glutathione repairs the mutated DNA by giving up an electron to the DNA (replacing the DNAs missing electron)