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The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

Communities are expressing a growing need to rapidly adapt urban environments to ongoing changes through a renewal process that integrates physical interventions in spaces with new housing models capable of responding to the demand for more inclusive, sustainable, and intelligent solutions

Bladder pain syndrome (interstitial cystitis) is a problem that causes pain in the bladder or pelvis

123 MizunoS.NakamuraT

L.et al (2009)