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This is also supported by research showing that women who smoke are more likely to conceive a chromosomally unhealthy pregnancy (such as a pregnancy affected by Down syndrome) than non-smoking mothers

Reports show that the impact of smoking on health and productivity costs the UK economy 17bn every year, 2.5bn of which is shouldered by the NHS

PMID 12390575

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Freebase is usually 3 to 18 mg