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Peptidemembrane interactions and mechanisms of membrane destruction by amphipathic -helical antimicrobial peptides

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2.4 Combining DPI, MitoQ and vincristine induces cell death of MNA NB cells To characterize the interaction between MitoQ, DPI, and vincristine, we assessed their effects on cell death at IC50/2 and IC50/3 concentrations in four NB cell lines: Be(2)-C (MNA), IMR-32 (MNA), IMR-5/75 (MNA with MYCN downregulatable), and SH-SY5Y/MYCN (non-MNA, MYCN-inducible)

Reported adverse events included rash, headache, nosebleed, fatigue, colds, and stomach flu

Journal of Physiology-Paris , 91, 173-178