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4.2 Adolescent fluoxetine and nicotine enhance function of D 2 dopamine receptors The induction of locomotor activity by quinpirole in adolescents is mediated by D 2 receptors and is age-specific ( 2 receptor function that occurs during adolescence ( 1A R mechanism and increases D 2 receptor expression and functional activity in the striatum ( 2 receptor is further indicated by the finding that D2 receptor blockade or knockdown during nicotine pretreatment of adolescents blocks subsequent enhancement of cocaine self-administration via a microglia-specific mechanism ( 2 receptor function in this age group

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