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2018;362:eaat8127

These enzymes may have initially evolved to conjugate naturally occurring compounds such as phenylpropanoids (Dean et al, 1995

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The subsequent condensation of C P -SOH occurs via the resolving C94 residue (C R ) in helix 2, resulting in HpTpx ox with an intramolecular disulfide bridge between C P and C R (Supplementary Fig