To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig
Proper storage and handling preserve peptide integrity and biological activity for reliable laboratory research
Beyond HIF-1 , the hypoxia-induced HIF-2 -dependent pathway promotes angiogenesis in breast cancer by upregulating levels of the lncRNA RAB1B-AS231 through HIF-2
(2015) Characterizing cellular biophysical responses to stress by relating density, deformability, and size Biophys
Prediction of novel therapeutics for emphysema In order to identify compounds that might reverse the gene-expression pattern associated with progression of emphysema, we utilized the CMap [13], a compendium of microarray experiments that measure the effect of therapeutic compounds on gene expression in cancer cell lines
