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Not a dealbreaker, but a step behind #1-3 on this list

The identification of probiotic strains, such as DM9218, capable of lowering uric acid levels represents a novel therapeutic avenue

Methionine assists in the breakdown of fats in the body, preventing buildup of fatty deposits in the blood vessels that might cause coronary artery disease and blockages in the neck and legs

Wu J, Jiang Z, Zhang H et al (2018) Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

Hydroxyl radicals generated via Fenton reactions directly increase cerebral edema by impairing ion homeostasis