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4d and Supplementary Fig

In hypertension, GAS5 is significantly downregulated in endothelial cells (ECs) and VSMCs, and its silencing exacerbates vascular remodeling, increases capillary leakage, and promotes endothelial dysfunction by modulating -catenin signaling

Key oxidative stress markers include glutathione levels, malondialdehyde, and 8-oxoguanine