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In time, progression from NAFLD to fibrosis (scarring) and cirrhosis (scarring of the liver) can result in hepatorenal syndrome, a complication marked by severe kidney malfunction with reduced kidney blood flow and abdominal edema (ascites)

Overweight in children and adolescents: Pathophysiology, consequences, prevention, and treatment

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

Research has described effects on fibroblast activity, including reported up-regulation of collagen, elastin, glycosaminoglycan, and decorin production in cellular models