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Oxidized LDLs have been implicated in the development of cardiovascular disease (4)

Wer NAD+ boosten will, sollte aktuell auf NR zurckgreifen

The concentration varies though from 1-2 mM in most cells to an impressive 10 mM in liver cells

FXR inhibits the transcription of the CYP7A1 gene by suppressing the expression of hepatic nuclear factor 1 and hepatic nuclear factor 4, which in turn inhibits SREBP1c and reduces lipid synthesis in the liver (Lu et al., 2000)