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Smoking decreases functional diversity of the epithelium To understand the effect of smoking habit, we first examined whether genes previously reported to be differentially expressed between current and never-smokers, based on bulk RNA-seq from bronchial airway epithelial brushings 9 , were similarly affected in each cell type independently

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b Model 1: F (1, 59) = 2.730, p = 0.104, R 2 = 0.044