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Rarely, hypersensitivity reactions can occur, for instance, urticaria (hives) or other allergic-type reactions have been reported in isolated cases

Symptoms of iron insufficiency fatigue, hair shedding, restless legs, exercise intolerance frequently appear well before ferritin drops below the standard cutoff

This selectivity is crucial because many methyltransferases play essential roles in neurotransmitter metabolism, gene expression, and protein function

Many people take oral or sublingual tablets, but they may not always be effective especially if absorption is poor

[108] In addition, certain drugs may interfere with laboratory tests for the vitamin, such as amoxicillin, erythromycin, methotrexate and pyrimethamine