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7.5 Saponins: guardians of mitochondrial integrity and lipid peroxidation Saponins protect against ALD by inhibiting CYP2E1 to reduce ROS generation during ethanol metabolism, while PPAR- activation promotes fatty acid -oxidation and HDL synthesis (Yang et al., 2021a

An 8 min gradient with flow rate of 500 L/min was used as follows: 01.0 min at 2% B

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Science 368, 473474

Consistent with this observation, all non-polar attachments proposed by GamePlan in subpocket C congregated near the piperazine ring of HEPE at the bottom of subpocket C (Fig