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Acknowledgements The authors gratefully acknowledge Fadwa Shokry Elbaz for her expertise in designing and illustrating the figures presented in this manuscript

Click to read the study in The Lancet Relevant Reading: Once-Weekly Semaglutide in Adults with Overweight or Obesity In-Depth [randomized controlled trial]: This study recruited individuals aged 18-55 years with a body-mass index 27.039.9 kg/m 2 from a single center