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This finding supports the idea that the mutation in pad2-1 close to the glutamate conjugating residues of GSH1 might influence the affinity of the enzyme for BSO, as it was proposed for cad2-1 54,71

FIGURE 3 4.2.1 Macrophage M2 polarization enhances osteo-vascular regeneration Natural products can effectively induce macrophage polarization toward the M2 phenotype, thereby mitigating chronic inflammation within the bone microenvironment, enhancing osteogenic differentiation of BMSCs, and indirectly promoting angiogenesis

10.1016/j.chemosphere.2011.04.022 Chemosphere 57 LoyallL.UchidaK.BraunS.FuruyaM.FrohnmeyerH