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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

Tone (Toner) Apply toner on a cotton pad, swipe over face & neck

These pathways originate from the striatum, which is composed of the putamen and caudate nucleus, and target different nuclei within the basal ganglia

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