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This is a pure handling optimization, entirely separate from the question of whether any amount should be modeled at all

Bai Y, Lu H, Lin C, Xu Y, Hu D, Liang Y, Hong W, Chen B (2016) Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis

A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss

In the case of study LOAZ, the use of healthy individuals necessitated that only very low (subtherapeutic), single OLAI doses could be studied because healthy individuals usually cannot tolerate therapeutic doses of antipsychotics (Cutler, 2001)

Chemokines in target cell tissues can also induce directed cell migration, initiate signal pathways, and monitor cytoskeletal rearrangment and adhesion (91)