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PKA catalyzes the polyphosphorylation of HSL on multiple sites, including a nonactivating site (Ser-563) as well as two additional sites (Ser-659 and Ser-660) that cause activation and subsequent translocation of this lipase from the cytosol to the lipid droplet (4, 51, 120)

For example: Fatigue, unexplained weight loss, or abdominal pain may indicate liver disease or cancer Easy bruising, night sweats, or feeling full quickly (early satiety) may suggest a myeloproliferative disorder Swelling in the legs, reduced urine output, or persistent nausea may point to kidney disease In cases of very high B12 from injections (not oral supplements), some people have reported headache, nausea, diarrhea, facial flushing, or skin rash