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The 6cys proteins and Hap2 protein were chosen as transmission blocking vaccine candidates after investigation of the genome annotation since these antigens were known to be involved in sexual stage development in other Babesia -related parasites, and then experimentally validated for Babesia parasites

Histopathology consistently showed solar elastosis and brownish-yellow, banana-shaped fibers between degenerated collagen fibers of the papillary dermis

Interestingly, both of the antioxidants, carnosine and uric acid, were also relatively decreased, while there were once again various metabolites associated with altered gut microbiota identified

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