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However, it is well known that such retrospective observational epidemiological studies on drug effects may be influenced by two main limitations, protopathic bias (i.e., dermatologists were treating presumed psoriatic arthritisPsA) and confounding by indication (i.e., dermatologists tended to use more TNF inhibitors in suspected PsA compared to IL-12/23 inhibitors) [5]

Single cell technology may be helpful in further breaking down the heterogeneous nature of tissue-residing effector T cells (59, 60), enabling the assignment of functional subsets to particularly patterns of nutrient uptake and utilization

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Indole-3-carbinol influences estrogen metabolism and dampens inflammatory signaling, potentially stabilizing mood and cognition (177179)