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An involvement of these brain regions is in accordance with other investigations conducted with the same ball tossing paradigm (9, 10, 41)

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And what are nicotine's effects in the body

Chronic Constipation and Diarrhea Slowed-down peristalsis due to the nicotine effect on smooth muscle cells found within walls of the intestines may lead to prolonged transit time, hence chronic constipation while increased activity can cause rapid passing of food leading to watery stools thus diarrhea