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These findings were compared to 69 mothers in Cambodia who were not given a vitamin B 12 supplement during pregnancy or lactation, and who had blood and milk collected one time between 3 and 27 weeks postpartum

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In studies combining NNMT inhibition with progressive weighted wheel running (an intensive concurrent endurance and resistance exercise protocol), treated mice exhibited sustained enhanced muscle performance suggesting reduced need for recovery between exercise sessions

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Dementia and depression have been associated with this deficiency as well, possibly from the under-production of methionine because of the inability to convert homocysteine into this product