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As we saw with depression, this elevated glutamate has an end-game: Recent studies have found dendritic remodeling, synaptic spine reductions, glial loss, and possibly volumetric reductions from glutamate excess following stress

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Stroke 36 , 17101715 (2005)

Rhonda Patrick: Because this has been shown with, for example, sulforaphane in animal studies

Supporting our cytochrome c assays, we confirmed no change in mitochondrial outer membrane permeabilization (MOMP) in cells surviving 5FU treatment (compared to the dimethyl sulfoxide group), and no increase in mitochondrial apoptotic priming based on BH3-profiling 15,16 induced by 5FU treatment (Extended Data Fig