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A metabolome atlas of the aging mouse brain

Iron overload may also deplete both GSH (reduced glutathione) and methyl donors, which are required for maintaining normal DNA methylation patterns (Ye et al., 2019), which could indirectly alter neurotransmission signaling pathways, thereby influencing mood and behavior

Glutathione for detox steps in to donate electrons, effectively regenerating these spent antioxidants and restoring their ability to combat oxidative stress