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GHK-Cu is one of the most widely studied peptidemetal complexes due to its ability to bind copper ions and influence multiple biological signaling pathways in research environments

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Another study (113) has also shown that AD can attenuate hypoxia-induced migration and invasion of RA-FLS and the expression of MMPs (MMP-1, MMP-3 and MMP-9) by inhibiting the HIF-1 signaling pathway

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