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Apply the patches to clean, dry, undamaged skin

Chronic inflammation disrupts endothelial integrity and reduces NO bioavailability, while inflammasomes like NOD-like receptor thermal protein domain associated protein 3 may activate oxidative stress, and finally aggravate vascular damage [70]

Safety profiles differ significantly by compound and evidence base

3.1 Diabetic atherosclerosis Previous research has demonstrated that diabetes mellitus and AS share the same endothelial pathological response (74)

The behavioral tests showed that, unlike wild-type mice, siP-Syn mice were able to resist cognitive impairment induced by chronic hypoxia (Fig