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Environmental stressors further modulated susceptibility: high ammonia levels damaged mucosal barriers and impaired tight junctions 107 , while thermal stress activated the hypothalamicpituitaryadrenal axis, inducing stress-related immunosuppression and weakening respiratory mucosal defense 108

Angiogenesis (Blood Vessel Formation): It promotes the formation of new blood vessels by stimulating VEGF (vascular endothelial growth factor), enhancing wound healing

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