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Temporary use may also be beneficial in Hashimotos or hypothyroidism while someone is working with their naturopathic doctor to address root causes

B12 injections circumvent these pathways entirely, delivering the full dose directly into the bloodstream where it is absorbed with near-complete efficiency

Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

For beginners you can start with morning doses to see if it suits you

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