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Some factors that influence how long the shot lasts include: Lifestyle and stress levels Diet and alcohol consumption Existing health conditions (e.g., pernicious anemia, digestive disorders) How quickly your body uses or excretes B12 If your energy starts fading or symptoms return before your next scheduled shot, let your provider know

You need to supplement with a daily multivitamin as well as folic acid when you start on B12

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Sergey Terushkin, MD, FACS Meet with a provider either in person or through a secure telehealth appointment

For more discussion of this concern, see our article on potential complications of BPC-157