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GSTs are involved in the main detoxification route of AFB1- exo -8,9-epoxide by catalyzing the conjugation of AFB1- exo -8,9-epoxide to endogenous GSH

Assuming Eli Lilly follows a similar timeline to tirzepatide, the earliest possible FDA approval for retatrutide would likely occur in late 2027 or 2028, depending on Phase 3 trial results and regulatory review timelines

It is thought to thought to interact with growth factors and cytokines, which are important signaling molecules that regulate cell growth, differentiation, and inflammation

2011 Oct;44(2):192-201

In addition, this review provided an overview of current therapeutic strategies targeting ROS, including both mitochondria-targeted antioxidants and conventional agents