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TF-induced thrombin cleaves C5 at a novel R947 site and forms new fragments, C5 T and C5b T (Krisinger et al., 2012)

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KPV is generally discussed as an immune-modulating or anti-inflammatory research peptide rather than a broad immunosuppressant

It is highly likely that the various phases of MS thus represent a continuum of the same disease, where autoimmune inflammation is most prominent early, gradually wanes with age, thus unmasking a progressive underlay of chronic cytodegenerative processes that are present from disease inception