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One Cochrane review found that high-dose oral vitamin B12 supplements (1,000 mcg to 2,000 mcg per day) was as effective for correcting megaloblastic anemia as B12 shots

But we can suppose, that not all short peptides can interact with histone protein, because some short peptides (for example AEDG, EDR, AEDL, KEDW) can have different biological activity and, may be, different molecular target points in the cell

Ipamorelin is well-tolerated long-term due to its selective action and low desensitization risk compared to older peptides like GHRP-2 or GHRP-6

Current Pharmaceutical Design , 20(7), 11211125

Toxicol Rep 7:1242