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Reactive oxygen species (ROS), together with reactive nitrogen species (RNS), represent the most important prooxidants whose excessive accumulation leads to oxidative stress (OxS) and molecular damage ( ROS are crucial in thyroid function because they are essential in the initial stages of thyroid hormone synthesis during iodide oxidation ( Aerobic organisms have evolved multiple antioxidant and repair systems for protection against OxS

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Zheng ZS, Wang J, Lee S, Wang KX, Zhang B, Howard M, et al

Neurology 45 , 18321836 (1995)